SHV-13, a novel extended-spectrum beta-lactamase, in Klebsiella pneumoniaeisolates from patients in an intensive care unit in Amsterdam

Authors
Yuan, MF Hall, LMC Savelkoul, PHM Vandenbroucke-Grauls, CMJE Livermore, DM
Citation
Mf. Yuan et al., SHV-13, a novel extended-spectrum beta-lactamase, in Klebsiella pneumoniaeisolates from patients in an intensive care unit in Amsterdam, ANTIM AG CH, 44(4), 2000, pp. 1081-1084
Citations number
17
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
4
Year of publication
2000
Pages
1081 - 1084
Database
ISI
SICI code
0066-4804(200004)44:4<1081:SANEBI>2.0.ZU;2-4
Abstract
Eleven clonally related Klebsiella pneumoniae isolates were examined. These had been isolated at an intensive care unit in Amsterdam in 1994. Their re sistance was associated with a conjugative 170-kb plasmid which encoded a n ovel SHV beta-lactamase designated SHV-13. The SHV-13 enzyme had two substi tutions compared with SHV-1: Leu35Gln and Gly238Ala. It hydrolyzed cefotaxi me much more rapidly than ceftazidime or aztreonam.