Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates

Authors
Warren, KE McCully, CM Walsh, TJ Balis, FM
Citation
Ke. Warren et al., Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates, ANTIM AG CH, 44(4), 2000, pp. 1100-1101
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
4
Year of publication
2000
Pages
1100 - 1101
Database
ISI
SICI code
0066-4804(200004)44:4<1100:EOFOTP>2.0.ZU;2-D
Abstract
Antifungal prophylaxis in cancer patients who are undergoing chemotherapy i s associated with prolonged neutropenia. We measured the effect of fluconaz ole on doxorubicin pharmacokinetics in nonhuman primates to determine if ne utropenia is related to a pharmacokinetic interaction that delays the clear ance of the chemotherapeutic agent. Fluconazole pretreatment had no effect on doxorubicin pharmacokinetics.