Ag. Tomasselli et Rl. Heinrikson, Targeting the HIV-protease in AIDS therapy: a current clinical perspective, BBA-PROT ST, 1477(1-2), 2000, pp. 189-214
Citations number
90
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
This review deals with clinical applications of compounds that inhibit the
action of the protease encoded within the genome of human immunodeficiency
virus (HIV). The HIV-protease is essential for viral maturation and represe
nts an important therapeutic target in the fight against AIDS. Following a
brief overview of the enzyme structure and function, the article focuses on
a number of peptide and non-peptide based HIV-protease inhibitors that are
in current clinical use. These drugs are discussed both with respect to th
eir efficacy in treatment of AIDS, and to problems related to insurgence of
viral resistance and side effects seen to date in patient populations. (C)
2000 Elsevier Science B.V. All rights reserved.