Efficient multigram synthesis of the bifunctional chelating agent (S)-1-p-isothiocyanatobenzyl-diethylenetetraminepentaacetic acid

Authors
Corson, DT Meares, CF
Citation
Dt. Corson et Cf. Meares, Efficient multigram synthesis of the bifunctional chelating agent (S)-1-p-isothiocyanatobenzyl-diethylenetetraminepentaacetic acid, BIOCONJ CHE, 11(2), 2000, pp. 292-299
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOCONJUGATE CHEMISTRY
ISSN journal
10431802 → ACNP
Volume
11
Issue
2
Year of publication
2000
Pages
292 - 299
Database
ISI
SICI code
1043-1802(200003/04)11:2<292:EMSOTB>2.0.ZU;2-F
Abstract
We have developed and optimized the synthesis of the title compound, elimin ating all HPLC purifications prior to the final product. The yield (and sca le) of the synthesis was increased from 19% (200 mg) to 75% (26 g).