Complete and regioselective deacetylation of peracetylated uridines using a lipase

Authors
Iglesias, LE Zinni, MA Gallo, M Iribarren, AM
Citation
Le. Iglesias et al., Complete and regioselective deacetylation of peracetylated uridines using a lipase, BIOTECH LET, 22(5), 2000, pp. 361-365
Citations number
12
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
BIOTECHNOLOGY LETTERS
ISSN journal
01415492 → ACNP
Volume
22
Issue
5
Year of publication
2000
Pages
361 - 365
Database
ISI
SICI code
0141-5492(200003)22:5<361:CARDOP>2.0.ZU;2-D
Abstract
Lipase-catalysed alcoholysis and hydrolysis of 2',3',5'-tri-O-acetyluridine (1a) and 2',3',5'-tri-O-acetyl-2'-C-methyluridine (1b) were studied. Condi tions for full and regioselective deacetylation of 1a and 1b are shown in t he present work. New compound 2',3'-di-O-acetyl-2'-C-methyluridine (3b) was prepared by regioselective lipase-catalysed deacetylation.