Stabilisation of immunoconjugates by trehalose

Citation
Mi. Esteves et al., Stabilisation of immunoconjugates by trehalose, BIOTECH LET, 22(5), 2000, pp. 417-420
Citations number
11
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
BIOTECHNOLOGY LETTERS
ISSN journal
01415492 → ACNP
Volume
22
Issue
5
Year of publication
2000
Pages
417 - 420
Database
ISI
SICI code
0141-5492(200003)22:5<417:SOIBT>2.0.ZU;2-M
Abstract
Stable immunoconjugates were prepared in the presence of 400 mM trehalose. Their residual activity after freeze-drying, rehydration and incubation for 9 h at 40 degrees C was 35%. Freeze-dried conjugates containing 400 mM tre halose incubated at 40 degrees C for 4 days retained 80% of their original activity.