Monoamines and sleep: microdialysis findings in pons and amygdala

This is the first microdialysis report comparing concentrations (pg/mu l) o f norepinephrine (NE), serotonin (5-HT) and dopamine (DA) derived from feli ne locus ceruleus complex (LC) and amygdala. NE and 5-HT declined progressi vely from waking to slow-wave-sleep (SWS) and then to rapid-eye-movement (R EM) sleep. Concentrations of DA did not change at either collection site ac ross the sleep-wake cycle. We conclude that release of NE and 5-HT release modulates physiologic components related to the sleep-wake cycle, but DA do es not. (C) 2000 Elsevier Science B.V. All rights reserved.