Measuring the activity of the disease in patients with cutaneous lupus erythematosus

The Systemic Lupus Activity Measure (SLAM) is a system proposed by rheumato logists to measure disease activity in their patients with systemic lupus e rythematosus (LE), It involves scoring a group of clinical symptoms and lab oratory findings, the maximum possible score being 84. In systemic LE, the mid-point is between 9 and 12, We applied SLAM to 176 patients with cutaneo us LE. Ninety-seven had localized discoid LE (L-DLE), 59 had disseminated d iscoid LE (D-DLE) and 20 had subacute cutaneous LE (SCLE). Eighty-five pati ents had low activity disease (0-4 points), 72 mildly active disease (5-9 p oints), 15 moderately active disease (10-14 points) and only four had very active disease (greater than or equal to 15 points), The most frequent lesi ons in patients who scored more than 10 points were photosensitivity, cicat ricial alopecia, Raynaud's phenomenon and oral ulcers, Fifty patients were followed up for more than 5 years (mean follow-up 9 years), Nine of these h ad an increased SLAM score. Seven had L-DLE, one D-DLE and one SCLE, Seven of the 50 patients had photosensitivity, five cicatricial alopecia, five no n-cicatricial alopecia, two Raynaud's phenomenon and two oral ulcers, Three patients who started with L-DLE evolved to D-DLE. The SLAM system is usefu l in the monitoring of disease activity in patients with cutaneous LE. Over time, even L-DLE patients may develop active disease. Photosensitivity, al opecia, oral ulcers and Raynaud's phenomenon seem to herald a worse prognos is.