Use of mycophenolate mofetil in the treatment of paraneoplastic pemphigus

Paraneoplastic pemphigus (PNP) is a rare autoimmune blistering disease with circulating antibodies that bind the cell surface of the epidermis and oth er non-stratifying epithelia, and immunoprecipitate a complex of four or fi ve proteins (250 kDa, 230 kDa, 210 kDa, 190 kDa and occasionally 170 kDa).( 1.2) Combinations of immunosuppressive agents are usually required to obtai n even partial control of the skin lesions.(3) Mucous membrane lesions are refractory to treatment. We describe a patient with PNP whose skill and ora l lesions are quiescent following treatment with oral mycophenolate mofetil .