Paraneoplastic pemphigus (PNP) is a rare autoimmune blistering disease with
circulating antibodies that bind the cell surface of the epidermis and oth
er non-stratifying epithelia, and immunoprecipitate a complex of four or fi
ve proteins (250 kDa, 230 kDa, 210 kDa, 190 kDa and occasionally 170 kDa).(
1.2) Combinations of immunosuppressive agents are usually required to obtai
n even partial control of the skin lesions.(3) Mucous membrane lesions are
refractory to treatment. We describe a patient with PNP whose skill and ora
l lesions are quiescent following treatment with oral mycophenolate mofetil
.