Length of use and symptoms associated with premature removal of the levonorgestrel intrauterine system: a nation-wide study of 17,360 users

Objective To establish the continuation rates of the levonorgestrel intraut erine system (LNG PUS) and symptoms associated with its premature removal. Sample and Setting All women in Finland who had a LNG; PUS inserted between April 1990 and December 1993 and whose doctor had filled in and returned a form at the insertion visit. This study population consists of 46% of all the LNG IUSs sold in Finland between 1990 and 1993. Design A questionnaire on reproductive and contraceptive history, gynaecolo gical problems and symptoms experienced during the use of the LNG PUS was s ent to 23,885 LNG PUS users. A total of 17,914 questionnaires were returned (response rate 75%). The results cover experience from 58,600 woman years. A log-rank-test was used to test differences in continuation rates. Multiv ariate analyse were performed using Cox's proportional hazard model. Results The LNG PUS was prematurely removed from 5175 women. The one, two, three, four and five year continuation rates were 93%, 87%, 81%, 75% and 65 %, respectively. The symptoms during the use of the LNG PUS most strongly a ssociated with its premature removal were excessive bleeding and spotting, and infections and pain. The risk of premature removal was markedly lower a mong women who had occasional or total absence of menstruation. Premature r emoval was less likely in the oldest age group. Conclusions The continuation rate of the LNG PUS compares favourably with o ther long-acting contraceptive systems. Totally or occasionally absent mens truation was strongly associated with prolonged continuation.