Progress of ossification and epithelialization of wounds after simple or surgical extractions of teeth in rats with chronic renal failure: an experimental study

Our aim was to investigate the progress of mound healing after simple and s urgical removal of the first two molars of the right and left maxillary seg ments, respectively, in Wistar rats with experimentally induced moderate ch ronic renal failure (CRF), Sixty Wistar rats were divided into two groups o f 30 rats each: experimental and control. CRF was induced in the experiment al group by an intraperitoneal injection of cisplatin, 5 mg/kg body weight (BW) initially and then with two maintenance doses of 2.5 mg/kg BW at inter vals of one month. The teeth were extracted one month after the last dose o f cisplatin, The sockets and the kidneys of all the rats of both groups wer e evaluated. The mandibles of the 15 rats in the experimental group that de veloped moderate CRE together with those of two controls, were evaluated fo r abnormalities that suggested renal osteodystrophy. The histopathological examination showed: (a) that there were no significant differences in the p attern of wound healing no matter how the tooth was extracted; (6) there we re no specific abnormalities in the mandible to indicate of secondary hyper parathyroidism or renal osteodystrophy; and (c) the kidneys of the rats of the experimental group underwent histopathological changes that were signif icantly different from those in the controls (P < 0.001). Our results indic ate that moderate CRF does not hare any appreciable or significant modifyin g effect on wound healing after tooth extraction in Wistar rats.