M. Dong et al., Ki-ras point mutation and p53 expression in human pancreatic cancer: A comparative study among Chinese, Japanese, and Western patients, CANC EPID B, 9(3), 2000, pp. 279-284
The aim of this study was to clarify features of Ki-ras point mutation (PM)
and p53 expression in Chinese pancreatic cancer and to compare those with
that in other countries. Dot blot hybridization and immunohistochemical met
hods were performed in 59 Chinese patients. The results showed that Ki-ras
PMs at codon 12 and p53 expression were frequent in this group, No relation
ships were found between Ki-ras PM alone and p53 expression alone, acid cli
nicopathological parameters, including age, gender, clinical stage, and his
tological grade and classification in Chinese patients. However, their coop
eration was significantly associated with a poor prognosis in this group. C
omparison showed that there were significant differences in the overall fre
quency and substitution of Ki-ras PM and in the ratio of transition:transve
rsion in pancreatic cancer among various countries. In addition, the effect
of Ki-ras PM and p53 expression on a poor prognosis of pancreatic cancer m
ay be different among various countries. These findings suggested that not
only Ki-ras PM and p53 expression are frequent in Chinese pancreatic cancer
, but also a gene component to pancreatic cancer may be different between A
sian and Western pancreatic cancer. In addition, it seems that cooperation
of Ki-ras PM and p53 expression mag predict a poor prognosis in Chinese pat
ients with pancreatic cancer.