Ki-ras point mutation and p53 expression in human pancreatic cancer: A comparative study among Chinese, Japanese, and Western patients

Citation
M. Dong et al., Ki-ras point mutation and p53 expression in human pancreatic cancer: A comparative study among Chinese, Japanese, and Western patients, CANC EPID B, 9(3), 2000, pp. 279-284
Citations number
32
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
ISSN journal
10559965 → ACNP
Volume
9
Issue
3
Year of publication
2000
Pages
279 - 284
Database
ISI
SICI code
1055-9965(200003)9:3<279:KPMAPE>2.0.ZU;2-G
Abstract
The aim of this study was to clarify features of Ki-ras point mutation (PM) and p53 expression in Chinese pancreatic cancer and to compare those with that in other countries. Dot blot hybridization and immunohistochemical met hods were performed in 59 Chinese patients. The results showed that Ki-ras PMs at codon 12 and p53 expression were frequent in this group, No relation ships were found between Ki-ras PM alone and p53 expression alone, acid cli nicopathological parameters, including age, gender, clinical stage, and his tological grade and classification in Chinese patients. However, their coop eration was significantly associated with a poor prognosis in this group. C omparison showed that there were significant differences in the overall fre quency and substitution of Ki-ras PM and in the ratio of transition:transve rsion in pancreatic cancer among various countries. In addition, the effect of Ki-ras PM and p53 expression on a poor prognosis of pancreatic cancer m ay be different among various countries. These findings suggested that not only Ki-ras PM and p53 expression are frequent in Chinese pancreatic cancer , but also a gene component to pancreatic cancer may be different between A sian and Western pancreatic cancer. In addition, it seems that cooperation of Ki-ras PM and p53 expression mag predict a poor prognosis in Chinese pat ients with pancreatic cancer.