As Helicobacter pylori plays an important role in the aetiopathogenesis of
peptic ulcer, therapeutic strategies aimed at maintaining long term remissi
on have shifted from the control of intragastric pH to targeting H. pylori.
According to recent international guidelines the clinical goals - rapid ni
cer healing and prevention of relapse - can be best accomplished by combina
tion therapy consisting of an antisecretory drug (proton pump inhibitor or
ranitidine) and 2 antimicrobial agents (preferable amoxicillin, clarithromy
cin or metronidazole).
When applying such multidrug regimens, possible synergy between the agents
suggests that pharmacokinetic considerations might help to improve H, pylor
i eradication rates, which should be above 85 to 90% on an intention-to-tre
at basis. The present review summarises the pharmacokinetic properties and
interaction potential of all drugs presently used in the various H. pylori
eradication regimens, with emphasis on particular patient populations such
as the elderly and those with renal impairment. The drugs considered are om
eprazole. lansoprazole, pontoprazole, rabeprazole. ranitidine and ranitidin
e bismutrex. bismuth salts. amoxicillin. clarithromycin, azithromycin, roxi
thromycin, metronidazole, tinidazole and tetracycline.
When addressing the clinically important questions of the efficacy, safety
and cost of the recommended regimens. the impact of drug disposition on H.
pylori eradication should not be neglected.