Implications of the UK Prospective Diabetes Study - Questions answered andissues remaining

Citation
Ad. Mooradian et J. Chehade, Implications of the UK Prospective Diabetes Study - Questions answered andissues remaining, DRUG AGING, 16(3), 2000, pp. 159-164
Citations number
15
Categorie Soggetti
Pharmacology,"Pharmacology & Toxicology
Journal title
DRUGS & AGING
ISSN journal
1170229X → ACNP
Volume
16
Issue
3
Year of publication
2000
Pages
159 - 164
Database
ISI
SICI code
1170-229X(200003)16:3<159:IOTUPD>2.0.ZU;2-Z
Abstract
The UK Prospective Diabetes Study (UKPDS) provides the first conclusive pro of for the importance of intensifying diabetes control in individuals with type 2 diabetes mellitus. However, reduction in cardiovascular disease risk with intensive therapy was modest and did not reach statistical significan ce. Metformin therapy in obese individuals with type 2 diabetes mellitus wa s associated with reduced cardiovascular death. These observations should b e re-evaluated to determine whether various therapeutic agents available fo r treatment of type 2 diabetes mellitus have different effects on cardiovas cular complications of diabetes. The addition of a-glucosidase inhibitor, a carbose, improved glycaemic control irrespective of concomitant therapy for diabetes, although compliance with this agent was poor. The tight blood pr essure control study embedded in UKPDS reaffirms the importance of lowering the blood pressure below 150/85 to reduce microvascular and macrovascular complications of diabetes.