Losartan - A review of its use, with special focus on elderly patients

Data Selection Sources: Medical literature published in any language since 1966 on Losarta n-potassium, identified using AdisBase (a proprietary database of Adis Inte rnational. Auckland, New Zealand), Medline and EMBASE. Additional reference s were identified from the reference lists of published articles. Bibliogra phical information. including contributory unpublished data. was also reque sted from the company developing the drug. Search strategy: AdisBase search terms were 'Losartan' and 'Congestive-hear t-failure' or 'Hypertension' or 'Elderly'. Medline search terms were 'Losar tan' and 'Heart-failure-congestive' or 'Hypertension' or 'Aged', Searches w ere last updated 10 January 2000, Selection: Studies in patients with hypertension and congestive heart failu re who received iosartan. inclusion of studies was based mainly on the meth ods section of the trials. When available, large, well controlled trials wi th appropriate statistical methodology were preferred. Relevant pharmacodyn amic and pharmacokinetic data are also included.