In the light of the gathering evidence for nu(mu)-nu(tau) neutrino oscillat
ions, coming in particular from the Super-Kamiokande data on atmospheric ne
utrinos, we re-analyze the unification of gauge and Yukawa couplings within
the minimal supersymmetric extension of the Standard Model (MSSM). Guided
by a range of different grand-unified models, we stress the relevance of la
rge mixing in the lepton sector for the question of bottom-tau Yukawa coupl
ing unification. We also discuss the dependence of the favoured value of ta
n beta on the characteristics of the high-energy quark and lepton mass matr
ices. In particular, we find that, in the presence of large lepton mixing,
Yukawa unification can be achieved for intermediate Values of tan beta that
were previously disfavoured. The renormalization-group sensitivity to the
structures of different mass matrices may enable Yukawa unification to serv
e as a useful probe of GUT models.