Investigation of the formation and properties of water-soluble conjugates of polymer p-nitrophenyl esters with polymer primary amines

UV spectroscopy was used to study the kinetics of intermolecular covalent i nteractions in the following system: a copolymer of N-(2-hydroxypropyl) met hacrylamide with p-nitrophenyl ester of p-methacryloylaminophenoxyacetic ac id - a copolymer of N-vinvlpyrrolidone with vinyl- or allylamine in dilute solutions in DMSO or in concentrated solutions in DMFA at 298 K. It was est ablished that the rate of the investigated reaction leading to the preparat ion of water-soluble branched polymers depends on the chemical nature of th e polymer p-nitrophenyl ester and polymer amine and on the molar ratio of t he reacting components, as well as the existence of additional interactions inside the polymer coil and on its conformation, The method of molecular h ydrodynamics were used to study the products of polymer-polymer reactions. It was found that depending on reaction conditions polymer-polymer conjugat es with different structures and different molecular weights (including con jugates with M-SD values higher by one order of magnitude than those of the initial reactive copolymers) can be obtained. (C) 2000 Elsevier Science Lt d. All rights reserved.