The most readily available source for autologous bone graft used in spinal
fusion (the gold standard) is the iliac crest. However, the open surgical a
pproach for harvesting corticocancellous iliac bone is associated with a ma
rked increase in morbidity. This study suggests two alternatives to the tra
ditional open harvesting procedure. For anterior interbody fusion procedure
s using a cage, the autologous bone is harvested regionally from a neighbor
ing vertebral body. Alternatively, using minimally invasive techniques, a c
ustom bone graft harvester with a flexible tube and cutting tip allows harv
esting of autologous bone from a single entry point at the iliac crest. The
effect on the mechanical strength of a lumbar vertebra of removing a cylin
drical regional bone graft was studied in a cadaveric model. The bone defec
t was Filled using three different filler materials: a porous tricalcium ph
osphate plug, a porous tantalum plug, and a self-setting calcium phosphate
cement. After plug removal, the vertebral body's strength in flexion/compre
ssion loading was reduced significantly, but could be restored to at least
intact values with any of the three filler materials. The minimally invasiv
e bone graft harvester was tested in three cadaveric pelves. With the cutti
ng tip being guided within the cortical boundaries of the pelvis, cancellou
s bone volumes of 10-20 cc could be harvested from each iliac bone. Regiona
l bone graft harvest in anterior spine surgery is suggested to be anatomica
lly safe and biomechanically acceptable. Any of the three filler materials
can restore the vertebral body's mechanical strength, but the filler's long
-term resorption/remodeling or osteointegration behavior is unknown. The mi
nimally invasive bone graft harvester is a novel tool, which performed sati
sfactorily under laboratory conditions, but clinical results are still miss
ing.