Effects of re-arterialization on early graft function and regeneration in the rat model of heterotopic auxiliary liver transplantation

In the rat model of heterotopic auxiliary liver transplantation, graft re-a rterialization may influence the outcome of inter-liver competition. This w as investigated in the current study using two transplanted groups with or without graft re-arterialization. Immediately after reperfusion, the re-art erialized grafts showed significantly higher bile flow rate and bilirubin e xcretion than the grafts without re-arterialization. DNA synthesis rate was also increased more drastically in the re-arterialized group following the transplantation. Without re-arterialization, the rats developed more prono unced cytolysis and cholestasis. Among the long-term survivors, all healthy re-arterialized grafts regenerated, whereas 5/6 non-re-arterialized grafts atrophied. These data demonstrate that the rearterialization increases gra ft survival by improving early hepatic function, enhancing regenerative res ponse and preventing post-transplant biliary complications in this rat mode l. Copyright (C) 2000 S. Karger AG, Basel.