Effects of mepartricin (S-160) on spontaneous canine benign prostatic hyperplasia

Objective: The effects of mepartricin (S-160) on spontaneous canine benign prostatic hyperplasia (BPH) were investigated by histological, histochemica l and biochemical analysis. Methods: Aged beagle dogs (5-9 years old) with spontaneously developed BPH were treated orally with a placebo or S-160 (5, 10 or 20 mg/kg/day) for 8 w eeks. The methodology included measurement of prostatic volume by transrect al ultrasonography, qualitative evaluation of prostatic morphology, determi nation of plasma and intraprostatic estradiol level by radioimmunoassay and immunohistochemical detection of estrogen receptors and androgen receptors in the prostate. Results: S-160 significantly reduced the prostatic volume and regressed his tologically the hyperplastic grade of prostate, and also fairly decreased t he plasma and intraprostatic estradiol concentration and the estrogen and a ndrogen receptors in the prostate. Conclusions: These results suggest that the reduction of estradiol and estr ogen receptors in the prostate may play a crucial role in the regression of BPH by S-160. Copyright (C) 2000 S. Karger AG, Basel.