Effect of high-grade prostatic intraepithelial neoplasia on total and percent free serum prostatic-specific antigen

Objective: To analyze the influence of high-grade prostatic intraepithelial neoplasia (HGPIN) on total serum prostatic-specific antigen (PSA) and perc ent free PSA. Methods: Total and free serum PSA were determined in 81 consecutive patient s with clinical Tie prostate cancer who underwent radical prostatectomy. HG PIN was detected in 62 specimens (76.5%). Results: Median total PSA was 9.2 ng/ml when there was not HGPIN and 8.1 ng /ml when it existed, p>0.05. Median percent free PSA was 11.7 and 9.1%, res pectively, p<0.03. However, a multiple linear regression analysis demonstra ted there was no effect: of HGPIN on total PSA nor on percent free PSA. Per cent free serum PSA was significantly influenced by total PSA and the patho logical tumor stage. Conclusion: HGPIN does not seem to contribute significantly on serum total PSA and percent free PSA. Copyright (C) 2000 S. Karger AG, Basel.