Electrochemical study of cefetamet-Na and its polarographic determination

Polarographic behavior of cephalosporin cefetamet-Na (Cef-Na) in aqueous so lutions of pH ranging from 1.7 to 12.5 was investigated by applying direct current (dc) polarography, differential pulse polarography (dpp), alternati ng current (ac) polarography, cyclic voltammetry and electrolysis at consta nt potential. The characteristics of the corresponding electrode reaction a re presented and discussed. The electrode reaction was found to be affected by strong adsorption, strongly and slightly pronounced in acidic and alkal ine media, respectively. The methoxyimino group electroreduction was carrie d out and the mechanistic scheme was suggested. In addition, a sensitive dp p method was proposed for analytical determination of a very low concentrat ions of Cef-Na. (C) 2000 Elsevier Science S.A. All rights reserved.