Effect of 7-methoxytacrine and L-carnitine on the activity of choline acetyltransferase

Authors
Bajgar, J Skopec, F Herink, J Patocka, J Kvetina, J
Citation
J. Bajgar et al., Effect of 7-methoxytacrine and L-carnitine on the activity of choline acetyltransferase, GEN PHYSL B, 18, 1999, pp. 3-6
Citations number
18
Categorie Soggetti
Physiology
Journal title
GENERAL PHYSIOLOGY AND BIOPHYSICS
ISSN journal
02315882 → ACNP
Volume
18
Year of publication
1999
Pages
3 - 6
Database
ISI
SICI code
0231-5882(199910)18:<3:EO7ALO>2.0.ZU;2-B
Abstract
Changes of choline acetyltransferase (ChAT) activity in the hippocampus and the basal ganglia were studied in rats treated i.p. with L-carnitine (CRT) and 7-methoxytacrine (7-MEOTA) (i.m.) separately or 5-days treated with L- carnitine and then with one administration of 7-MEOTA. Both compounds incre ased ChAT activity when administered separately. S-day treatment of CRT fol lowed by administration of 7-MEOTA normalized ChAT activity.