The potential teratogenicity of the antioxidant stobadine (STO) was studied
in Wistar rats. Daily oral doses of 5, 15 and 50 mg/kg STO were given from
the 6th day of gestation up to weaning of pups - day 21 post partum. No si
gnificant differences between the STO treated groups and the control group
were found in litter size, pre- and postimplantation losses and foetal body
weight. External, skeletal and internal examinations of the foetuses revea
led no evidence of teratogenesis. The offspring from the STO treated dams e
xhibited a high survival rate in their postnatal development. It can be con
cluded that STO had no adverse effects on the pre- and postnatal developmen
t of the offspring in rats.