Teratological study of the antioxidant stobadine in rats

The potential teratogenicity of the antioxidant stobadine (STO) was studied in Wistar rats. Daily oral doses of 5, 15 and 50 mg/kg STO were given from the 6th day of gestation up to weaning of pups - day 21 post partum. No si gnificant differences between the STO treated groups and the control group were found in litter size, pre- and postimplantation losses and foetal body weight. External, skeletal and internal examinations of the foetuses revea led no evidence of teratogenesis. The offspring from the STO treated dams e xhibited a high survival rate in their postnatal development. It can be con cluded that STO had no adverse effects on the pre- and postnatal developmen t of the offspring in rats.