Developmental defects and chromosomal aberrations in spontaneous abortionsand stillbirths

Authors
Vojtassak, J Malova, J Demjenova, L Martanovic, P Bohmer, D Korbel, M Danihel, L Fiala, P Durikova, M Braxatorisova, T Geislerova, V Pagacova, E
Citation
J. Vojtassak et al., Developmental defects and chromosomal aberrations in spontaneous abortionsand stillbirths, GEN PHYSL B, 18, 1999, pp. 182-188
Citations number
14
Categorie Soggetti
Physiology
Journal title
GENERAL PHYSIOLOGY AND BIOPHYSICS
ISSN journal
02315882 → ACNP
Volume
18
Year of publication
1999
Pages
182 - 188
Database
ISI
SICI code
0231-5882(199910)18:<182:DDACAI>2.0.ZU;2-4
Abstract
The authors analysed 1488 cases of spontaneous abortions and stillbirths in Bratislava. They focused on the course of human embryogenesis and the chro mosomal constitution. A high mean frequency rate of both developmental defe cts (14.4%) and chromosomal aberrations (33.6%) was revealed and both were found to be in close relation with the length of gestation. The most severe developmental defects occurred mostly in early stages of human embryogenes is, i.e. in the 1(st) trimester of gestation.