Detailed comparative gene map of rat chromosome 1 with mouse and human genomes and physical mapping of an evolutionary chromosomal breakpoint

We report the localization of 92 new gene-based markers assigned to rat chr omosome 1 by linkage or radiation hybrid mapping. The markers were chosen t o enrich gene mapping data in a region of the rat chromosome known to conta in several of the principal quantitative trait loci in rodent models of hum an multifactorial disease. The composite map reported here provides map inf ormation on a total of 139 known genes, including 80 that have been localiz ed in mouse and 109 that have been localized in human, and integrates the g ene-based markers with anonymous microsatellites. The evolutionary breakpoi nts identifying 16 segments that are homologous regions in the human genome are defined. These data will facilitate genetic and comparative mapping st udies and identification of novel candidate genes for the quantitative trai t loci that have been localized to the region. (C) 2000 Academic Press.