Actions and interactions of the IGF system in Alzheimer's disease: review and hypotheses

Authors
Lackey, BR Gray, SL Henricks, DM
Citation
Br. Lackey et al., Actions and interactions of the IGF system in Alzheimer's disease: review and hypotheses, GROWTH H I, 10(1), 2000, pp. 1-13
Citations number
184
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
GROWTH HORMONE & IGF RESEARCH
ISSN journal
10966374 → ACNP
Volume
10
Issue
1
Year of publication
2000
Pages
1 - 13
Database
ISI
SICI code
1096-6374(200002)10:1<1:AAIOTI>2.0.ZU;2-O
Abstract
Insulin-like growth factors (IGF) are pleiotrophic polypeptides affecting a ll aspects of growth and development. The IGF system, including ligands, re ceptors, binding proteins and proteases is also involved in pathophysiologi cal conditions, such as cancer and degenerative conditions. In this review, the actions and interactions of the IGF system as it relates to Alzheimer' s disease will be investigated. (C) 2000 Harcourt Publishers Ltd.