We report the successful use of valproate in a 14-year-old woman with migra
ine induced by selective serotonin reuptake inhibitors. Valproate should be
considered for those patients who develop serious migraine for the first t
ime, or worsening of previous migraine, after the initiation of treatment w
ith selective serotonin reuptake inhibitors and for whom continued treatmen
t with this class of drugs is important.