Chondromyxoid fibroma is a rare benign bone tumor most commonly arising in
the metaphysis of long bones in young adults. Histopathologically, chondrom
yxoid fibroma may be difficult to distinguish from other cartilaginous neop
lasms. Recently, a pericentric inversion of chromosome 6 [inv(6)(p25q13)] h
as been proposed as a specific genetic marker for chondromyxoid fibroma, In
this study, cytogenetic and spectral karyotypic analyses of 2 chondromyxoi
d fibroma cases showed clonal abnormalities of chromosome 6 but at a breakp
oint on the long arm (q25) distal to that described in the pericentric inve
rsion. These findings suggest that several distinct breakpoints on chromoso
me 6 are nonrandomly involved in chondromyxoid fibroma. Copyright (C) 2000
by W.B. Saunders Company.