Recurrent anomalies of 6q25 in chondromyxoid fibroma

Chondromyxoid fibroma is a rare benign bone tumor most commonly arising in the metaphysis of long bones in young adults. Histopathologically, chondrom yxoid fibroma may be difficult to distinguish from other cartilaginous neop lasms. Recently, a pericentric inversion of chromosome 6 [inv(6)(p25q13)] h as been proposed as a specific genetic marker for chondromyxoid fibroma, In this study, cytogenetic and spectral karyotypic analyses of 2 chondromyxoi d fibroma cases showed clonal abnormalities of chromosome 6 but at a breakp oint on the long arm (q25) distal to that described in the pericentric inve rsion. These findings suggest that several distinct breakpoints on chromoso me 6 are nonrandomly involved in chondromyxoid fibroma. Copyright (C) 2000 by W.B. Saunders Company.