Cross-sectionally, higher weight is associated with higher blood pressure l
evels; prospectively, baseline weight and weight gain predict higher blood
pressure. The loss of weight is frequently associated with a decrease in bl
ood pressure. These findings suggest that weight gain may pathophysiologica
lly contribute to blood pressure elevation. In this review, we present data
to indicate that the reverse is also true; persons of equal weight who had
higher initial blood pressures gain more weight in the future. We also pro
pose a plausible hypothesis to explain this reverse relationship. Both the
blood pressure elevation and the gain of weight may reflect a primary incre
ase in sympathetic tone. It is well known that in a milieu of increased sym
pathetic tone, the beta-adrenergic responsiveness decreases. Sympathetic ov
eractivity and decreased cardiovascular beta-adrenergic responsiveness have
been described in hypertension. beta-Adrenergic receptors mediate increase
s in energy expenditure. If these metabolic receptors were downregulated in
hypertension, the ability of hypertensive patients to dissipate calories w
ould decrease and they would gain more weight. The possible relationship of
decreased beta-adrenergic responsiveness to weight in hypertension can be
experimentally tested. Such research may contribute to an explanation of wh
y patients with hypertension can rarely lose weight. An understanding of th
is pathophysiological relationship may open new avenues for therapeutic int
erventions.