Our objective was to determine if suckling neonatal piglets are susceptible
to enterohemorrhagic Escherichia coli (EHEC) O157:H7 disease. Surprisingly
, EHEC O157:H7 caused more-rapid and more-severe neurological disease in su
ckling neonates than in those fed an artificial diet. Shiga toxin-negative
O157:H7 did not cause neurological disease but colonized and caused attachi
ng-and-effacing intestinal lesions.