The HIV-AIDS epidemic in Latin America has produced an unexpected additiona
l burden to health care systems and national economies already weak and aff
ected by severe problems. Specific regional diseases, such as Chagas' disea
se, leishmaniasis, and histoplasmosis, in addition to common opportunistic
infections, and particularly the high incidence of tuberculosis, produce a
slightly different epidemiologic picture compared with the United States an
d Europe. Access to antiretrovirals is not universal in Latin America. Neve
rtheless, some countries are providing highly active antiretroviral therapy
to all eligible patients, showing that it is not impossible to improve the
quality of care for people living with AIDS in the region. Drug interactio
ns between antiretrovirals and specific treatments for regional diseases ge
nerate additional concerns for the already complex picture of the HIV-AIDS
epidemic in the region.