Chest pain is a common presentation to both primary and secondary care phys
icians but is often non-cardiac in origin. Patients presenting with chest:
pain may be experiencing a panic attack. Panic disorder is a disabling psyc
hiatric condition with serious consequences, such as impaired social functi
oning and increased risk of suicide. Comorbidity of panic disorder with oth
er psychiatric conditions is common and often leads to increased severity o
f anxiety symptoms and a poorer prognosis. The cost of misdiagnosing non-ca
rdiac chest pain is high. it is important for physicians to be able to reco
gnise panic attacks and to distinguish them from cardiac disease, thus avoi
ding unnecessary use of healthcare resources. This review discusses the pre
valence and diagnosis of panic attack and panic disorder in patients presen
ting with chest pain to primary care physicians and cardiologists. Treatmen
t options for panic disorder are considered, particularly the selective ser
otonin reuptake inhibitors, which are emerging as the first-line choice for
the treatment of panic disorder.