The present study was aimed at investigating the use of a treadmill fo
r ambulation training of paraplegic subjects. To investigate the likel
y effectiveness of this modality of rehabilitation, six paraplegic pat
ients (three male and three female) were studied, using new generation
reciprocating gait orthoses (RGO and ARGO), in a treadmill training p
rogram. Oxygen consumption, heart rate, and pulmonary ventilation were
measured when the subjects were walking at their most comfortable spe
ed on the treadmill and on the open field. These measurements were car
ried out at the beginning of the study and after two and six months of
treadmill training. The following findings were significant: the trea
dmill walking required 30% less energy than open field ambulation prio
r to training (P < 0.001) and 50% after training (P < 0.05). The most
comfortable walking speed was faster on the treadmill than on the open
field by 18% prior to training (P < 0.05) and 42% afterwards (P < 0.0
5). The energy cost was 50% less after 2 months training on the treadm
ill (P < 0.05) showing that treadmill training can improve the efficie
ncy of over ground ambulation. It can be concluded that the treadmill
training improves the RGO/ARGO walking capability, probably both the w
alking efficiency (short term adaptation) and physical fitness (long t
erm adaptation).