Caspase recruitment domain (CARD)-dependent cytoplasmic filaments mediate bcl10-induced NF-kappa B activation

Mucosa-associated lymphoid tissue (MALT) lymphomas are associated with over expression and constitutive activity of bcl10, a caspase recruitment domain (CARD)-containing protein that activates NF-kappa B, Here, we show that ar rangement of overexpressed bcl10 protein in cytoplasmic filaments is essent ial for recruitment of signal transducer molecules-involved NF-kappa B acti vation. We also show that cytoskeleton elements regulate bcl10 signaling, Thus, organized assemblage of proteins in ordered structures linked to the cytoskeleton network may represent a general mechanism for intracellular si gnaling.