S. Cherkaoui et Jl. Veuthey, Development and robustness testing of a nonaqueous capillary electrophoresis method for the analysis of nonsteroidal anti-inflammatory drugs, J CHROMAT A, 874(1), 2000, pp. 121-129
Nine non steroidal anti-inflammatory drugs were simultaneously separated by
nonaqueous capillary electrophoresis with a methanol-acetonitrile (40:60,
v/v) mixture containing 20 mM ammonium acetate. The effect of solvent compo
sition, electrolyte nature and concentration on the electrophoretic behavio
r of the selected drugs was systematically studied. Investigated electrolyt
es were ammonium, lithium and sodium acetate. Modification of the solvent a
nd/or the electrolyte composition was found to alter the migration order of
the pharmaceutical drugs. Finally, to assess method robustness, three sens
itive electrophoretic parameters as well as their interactions were evaluat
ed using a full factorial design at two levels. (C) 2000 Elsevier Science B
.V. All rights reserved.