Nitrofurantoin-induced lung disease: Two cases demonstrating resolution ofapparently irreversible CT abnormalities

Authors
Sheehan, RE Wells, AU Milne, DG Hansell, DM
Citation
Re. Sheehan et al., Nitrofurantoin-induced lung disease: Two cases demonstrating resolution ofapparently irreversible CT abnormalities, J COMPUT AS, 24(2), 2000, pp. 259-261
Citations number
16
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
ISSN journal
03638715 → ACNP
Volume
24
Issue
2
Year of publication
2000
Pages
259 - 261
Database
ISI
SICI code
0363-8715(200003/04)24:2<259:NLDTCD>2.0.ZU;2-#
Abstract
A reticular pattern on high resolution CT (HRCT) invariably represents sign ificant lung pathology and is the dominant feature of irreversible fibrosis . We present two cases of nitrofurantoin-induced pulmonary toxicity in whic h the initial HRCT showed a widespread reticular pattern and associated dis tortion of the lung parenchyma, thought to represent established fibrosis. Follow-up HRCT scans after withdrawal of the drug showed resolution of this supposedly irreversible pattern.