Cytotoxicity of cyanoacrylate adhesives to cultured tendon cells

The in vitro cytotoxicity of four cyanoacrylate adhesives,vas tested using cultures of cells derived from human tendons. All four mere found to be cyt otoxic, even at concentrations as low as 1.7%, over the experimental period of up to 18 weeks, This study shows that such adhesives in their present s tate may not be suitable for re-joining cut tendons as their initial and lo ng-term toxicity may hinder the slow healing process of tendons.