Histoplasmosis of the wrist

We present a case of synovitis of the wrist due to histoplasmosis, diagnose d only after extensive surgery and culturing. Treatment with amphotericin B in combination with radical surgery was effective in curing the disease. T his manifestation was probably an exacerbation of a latent chronic infectio n with Histoplasma capsulatum, although it was unclear why the exacerbation occurred. Synovitis resistant to treatment should be assessed with great c are, especially in view of the growing number of immunocompromised patients . Close collaboration between surgeon, rheumatologist, pathologist and micr obiologist is paramount in such cases.