Cutting edge: The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)

We recently reported the identification of a chemokine (CTACK), which has b een renamed CCL27 according to a new systematic chemokine nomenclature. We report that CCL27 binds the previously orphan chemokine receptor GPR-2, as detected by calcium flux and chemotactic responses of GPR-2 transfectants, We renamed this receptor CCR10, Because of the skin-associated expression p attern of CCL27, we focused on the expression of CCL27 and CCR10 in normal skin compared with inflammatory and autoimmune skin diseases, CCL27 is cons titutively produced by keratinocytes but can also be induced upon stimulati on with TNF-alpha and IL-1 beta, CCR10 is not expressed by keratinocytes an d is instead expressed by melanocytes, dermal fibroblasts, and dermal micro vascular endothelial cells. CCR10 was also detected in T cells as well as i n skin-derived Langerhans cells, Taken together, these observations suggest a role for this novel ligand/receptor pair in both skin homeostasis as wel l as a potential role in inflammatory responses.