Epoxidation of indene by chloroperoxidase

Authors
Manoj, KM Lakner, FJ Hager, LP
Citation
Km. Manoj et al., Epoxidation of indene by chloroperoxidase, J MOL CAT B, 9(1-3), 2000, pp. 107-111
Citations number
19
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
ISSN journal
13811177 → ACNP
Volume
9
Issue
1-3
Year of publication
2000
Pages
107 - 111
Database
ISI
SICI code
1381-1177(20000320)9:1-3<107:EOIBC>2.0.ZU;2-N
Abstract
The stereochemistry of the chloroperoxidase-catalyzed epoxidation of indene has been elucidated. In aqueous solution the intial epoxide product is not stable and opens to form the cis-trans diols. When the reaction was carrie d out in the absence of water, the epoxide enantiomers could be isolated. U nder these conditions in 1 R2S enantiomer was formed in approximately 30% e e. (C) 2000 Elsevier Science B.V. All rights reserved.