Bh. Hoff et al., Influence of substituents on enantiomeric ratio in transesterification of racemic C-3 synthons using lipase B from Candida antarctica, J MOL CAT B, 8(1-3), 2000, pp. 51-60
The fluorides, chlorides and bromides of 3-halo-1-phenoxy-2-propanol, 3-hal
o-1-phenylmethoxy-2-propanol and 3-halo-1-(2-phenylethoxy)-2-propanol have
been resolved by transesterification with various butanoates as acyl donors
in hexane and lipase B from Candida antarctica (Novozyme 435) as catalyst.
The enantiomeric ratio E depended on the hydroxy protecting groups in 1-po
sition and the halogens in 3-position. For some substrates, the enantiomeri
c ratio was dependent on the acylating agent. (C) 2000 Elsevier Science B.V
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