Three new triterpenoids from Peganum nigellastrum

Authors
Ma, ZZ Hano, Y Nomura, T Chen, YJ
Citation
Zz. Ma et al., Three new triterpenoids from Peganum nigellastrum, J NAT PROD, 63(3), 2000, pp. 390-392
Citations number
14
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
3
Year of publication
2000
Pages
390 - 392
Database
ISI
SICI code
0163-3864(200003)63:3<390:TNTFPN>2.0.ZU;2-A
Abstract
Three new triterpenoids, 3 alpha,27-dihydroxylup-20(29)-en-28-oic acid meth yl ester, 3 alpha-acetoxy-27-hydroxylup-20(29)-en-28-oic acid methyl ester, and 3 alpha-acetoxyolean-12-ene-27,28-dioic acid 28-methyl ester, were iso lated from the roots of Peganum nigellastrum along with four known lupene-t ype triterpenoids. The structures of the new triterpenoids were determined by NMR spectroscopic means. The new triterpene, 3 alpha,27-dihydroxylup-20( 29)-en-28-oic acid methyl ester is a DNA topoisomerase II inhibitor (IC50 = 8.9 mu M/mL).