PU.1 expression in microglia

Authors
Walton, MR Gibbons, H MacGibbon, GA Sirimanne, E Saura, J Gluckman, PD Dragunow, M
Citation
Mr. Walton et al., PU.1 expression in microglia, J NEUROIMM, 104(2), 2000, pp. 109-115
Citations number
41
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF NEUROIMMUNOLOGY
ISSN journal
01655728 → ACNP
Volume
104
Issue
2
Year of publication
2000
Pages
109 - 115
Database
ISI
SICI code
0165-5728(20000501)104:2<109:PEIM>2.0.ZU;2-X
Abstract
The transcription factor PU.1 has a pivotal role in both the generation and function of macrophages. To determine whether PU.1 is also involved in mic roglial regulation, we investigated its expression following hypoxic-ischem ia (HI) brain injury and in the BV-2 microglial cell line. We found that mi croglia constitutively expressed high levels of PU.1 protein in both their 'resting' and 'activated' states. (C) 2000 Elsevier Science B.V. All rights reserved.