SQUAMOUS-CELL CARCINOMA IN PERINEAL INFLAMMATORY DISEASE

Four patients with squamous cell carcinoma of the perineal region were diagnosed and treated during the last 4 years in our institutions, Th e underlying diagnoses consisted of recurrent pilonidal disease, Crohn 's disease, and hidradenitis suppurativa, In all patients, a pattern o f a long-term inflammatory process was evident, Current concepts regar ding the pathophysiology of a chronic inflammatory state and malignant transformation are reviewed, We conclude that regardless of the origi nal pathology, all chronic inflammatory processes in the perineal regi on should be evaluated for malignant degeneration. A high index of sus picion may potentiate an early diagnosis, possibly improving the chanc e of cure.