ENZYMATIC-SYNTHESIS OF OPTICALLY-ACTIVE MONO-ALKYLATED MALONIC MONOESTERS

Authors
KLOTZBERENDES B KLEEMISS W JEGELKA U SCHAFER HJ KOTILA S
Citation
B. Klotzberendes et al., ENZYMATIC-SYNTHESIS OF OPTICALLY-ACTIVE MONO-ALKYLATED MALONIC MONOESTERS, Tetrahedron : asymmetry, 8(11), 1997, pp. 1821-1823
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
11
Year of publication
1997
Pages
1821 - 1823
Database
ISI
SICI code
0957-4166(1997)8:11<1821:EOOMMM>2.0.ZU;2-X
Abstract
Pig-liver esterase hydrolysis of tertiary-alkyl malonic diesters 1 lea ds to malonic monoesters 2 in high yields and with enantiomeric excess es up to 96% ee. The configuration of the new stereogenic carbon atom was determined by crystal structure analysis of the (S)-1-phenylethyla mide of 2b. The monoesters 2 are stable against racemisation between p H 2 to pH 12 as shown for 2b. (C) 1997 Elsevier Science Ltd.