Outcomes after intravesical bacillus Calmette-Guerin are not affected by substaging of high grade T1 transition cell carcinoma

Citation
Fi. Kondylis et al., Outcomes after intravesical bacillus Calmette-Guerin are not affected by substaging of high grade T1 transition cell carcinoma, J UROL, 163(4), 2000, pp. 1120-1123
Citations number
22
Categorie Soggetti
Urology & Nephrology","da verificare
Journal title
JOURNAL OF UROLOGY
ISSN journal
00225347 → ACNP
Volume
163
Issue
4
Year of publication
2000
Pages
1120 - 1123
Database
ISI
SICI code
0022-5347(200004)163:4<1120:OAIBCA>2.0.ZU;2-0
Abstract
Purpose: Substaging of T1 bladder tumors into T1a and T1b based on invasion of the tumor superficial to and beyond the muscularis mucose has been assi gned prognostic significance. We determined whether outcomes after intraves ical bacillus Calmette-Guerin (BCG) differ between stage T1a and T1b subcat egories. Materials and Methods: Retrospective pathological evaluation of the initial , transurethral resection specimens of stage T1 bladder tumors was performe d by 2 pathologists. Grade 1, 2 or 3 and stage T1a or T1b were assigned to each case. Followup was from the date of transurethral resection to date of death or the last visit. Kaplan-Meier probability and log rank test were u sed to evaluate recurrence and progression. Results: Substaging was performed in 49 of the 55 patients (89%) with stage T1 disease. Disease was stage T1a in 32 (65%), stage T1b in 17 (35%), grad e 3 in 45 (92%) and grade 2 in 4 (8%) cases. Maximum followup was 147 month s (median 71) and 28 cases had a minimum of 5 years of followup. Recurrence was noted in 33 cases (67.3%), including 22 stage T1a (69%) and 11 stage T 1b (65%), at a median followup of 11.3 and 8.6 months, respectively. Progre ssion to a higher stage of disease was recorded in 12 cases (24.4%), includ ing 7 (22%) stage T1a and 5 (29%) stage T1b, at a median followup of 108 an d 120 months, respectively. The difference between T1a and T1b subcategorie s was not statistically significant in regard to recurrence-free (p = 0.720 3) and progression-free (p = 0.574) outcomes. Conclusions: Substaging of T1 tumors did not affect response to BCG in rega rd to recurrence or progression. Therefore, intravesical BCG is effective f or stages T1a and T1b disease.