Fi. Kondylis et al., Outcomes after intravesical bacillus Calmette-Guerin are not affected by substaging of high grade T1 transition cell carcinoma, J UROL, 163(4), 2000, pp. 1120-1123
Purpose: Substaging of T1 bladder tumors into T1a and T1b based on invasion
of the tumor superficial to and beyond the muscularis mucose has been assi
gned prognostic significance. We determined whether outcomes after intraves
ical bacillus Calmette-Guerin (BCG) differ between stage T1a and T1b subcat
egories.
Materials and Methods: Retrospective pathological evaluation of the initial
, transurethral resection specimens of stage T1 bladder tumors was performe
d by 2 pathologists. Grade 1, 2 or 3 and stage T1a or T1b were assigned to
each case. Followup was from the date of transurethral resection to date of
death or the last visit. Kaplan-Meier probability and log rank test were u
sed to evaluate recurrence and progression.
Results: Substaging was performed in 49 of the 55 patients (89%) with stage
T1 disease. Disease was stage T1a in 32 (65%), stage T1b in 17 (35%), grad
e 3 in 45 (92%) and grade 2 in 4 (8%) cases. Maximum followup was 147 month
s (median 71) and 28 cases had a minimum of 5 years of followup. Recurrence
was noted in 33 cases (67.3%), including 22 stage T1a (69%) and 11 stage T
1b (65%), at a median followup of 11.3 and 8.6 months, respectively. Progre
ssion to a higher stage of disease was recorded in 12 cases (24.4%), includ
ing 7 (22%) stage T1a and 5 (29%) stage T1b, at a median followup of 108 an
d 120 months, respectively. The difference between T1a and T1b subcategorie
s was not statistically significant in regard to recurrence-free (p = 0.720
3) and progression-free (p = 0.574) outcomes.
Conclusions: Substaging of T1 tumors did not affect response to BCG in rega
rd to recurrence or progression. Therefore, intravesical BCG is effective f
or stages T1a and T1b disease.