Control of Sindbis virus infection by antibody in interferon-deficient mice

Authors
Byrnes, AP Durbin, JE Griffin, DE
Citation
Ap. Byrnes et al., Control of Sindbis virus infection by antibody in interferon-deficient mice, J VIROLOGY, 74(8), 2000, pp. 3905-3908
Citations number
20
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
74
Issue
8
Year of publication
2000
Pages
3905 - 3908
Database
ISI
SICI code
0022-538X(200004)74:8<3905:COSVIB>2.0.ZU;2-9
Abstract
Antibodies clear Sindbis virus from infected animals through an unknown mec hanism. To determine whether interferon-induced pathways are required for t his clearance, we examined mice which are unable to respond to alpha/beta i nterferon or gamma interferon, Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sind bis virus were given.