Th. Malik et al., Characterization of the P protein-binding domain on the 10-kilodalton protein of Borna disease virus, J VIROLOGY, 74(7), 2000, pp. 3413-3417
The Borna disease virus (BDV) is the prototype member of the Bornaviridae,
and it replicates in the cell nucleus. The BDV p24P and p40N proteins carry
nuclear localization signals (NLS) and are found in the nuclei of infected
cells. The BDV p10 protein does not have an NLS, but it binds with P and/o
r N and is translocated to the nucleus. Hence, p10 may play a role in the r
eplication of BDV in the cell nucleus. Here, we show that the P-binding dom
ain is located in the N terminus of p10 and that S-3 and L-16 are important
for the interaction.