Dose-intensive therapy with hematopoietic cell transplantation is effective
at reversing AL amyloidosis but is not without risk. Guidelines have been
developed for patient selection in order to maximize benefit and minimize t
reatment-related mortality, Identification of a patient's clonal germline l
ight chain variable region gene may become relevant to patient selection, a
nd development of less morbid approaches to stem cell mobilization and coll
ection would be helpful. While there is room for discussion regarding the d
esign of future therapeutic trials, it is reasonable to attempt to improve
the complete response rate for good risk patients by continuing efforts on
the phase II level, Attempts to improve outcomes for patients with symptoma
tic cardiac or advanced multisystem disease may require serial solid organ
and stem cell transplantation as well as the development of less toxic appr
oaches using lower doses of melphalan, improved supportive care measures an
d specific organ-system prophylaxis. If outcomes can be improved, issues re
lated to clonotypic contamination of stem cells will need to be revisited.